Don't give me any grief. 不要叫我担心你.
Don't give me a hard time. 不要给我难堪. 不要故意找我麻烦. Don't be difficult. 不要化简为繁.
Don't make my life miserable. 不要使我度日如年.
What's with him? 他怎么啦? A:You okay? 你没事吧?