What's bothering you? 什么事困扰你呀?
What's bugging you? 什么事使你忧戚不宁?
What's on your mind .你到底有什么心事? What's the matter? You seem troubled. 怎么啦? 好像你被什么困扰.
What's eating him? 什么事使他坐立不安? Nothing's the matter? 没什么要紧的事吧?
What's the matter? 怎么啦?
What's wrong? 出什么错了?
