What the heck is this? 这是什么鬼东西呀?
What's the combination? 这个对号锁的密码是什么? What do you call this? 这东西你怎么称呼的? 你这算什么? What did you say? I didn't hear you. 你刚才说什么呢? 我没听清楚. A:May I ask you something? 可以请教你一点儿事吗? B:Go ahead. Shoot! 请说. 你说吧!
Mind if I ask you something personal? 你介意我问一点儿私事吗? It never hurts to ask. 开口请教别人, 绝对没有坏处.